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Studies of Drug Safety during Pregnancy

​​​Psychiatry and Neurology
  1. Straub L, Hernández-Díaz S, Bateman BT, Wisner KL, Gray KJ, Pennell PB, Lester B, McDougle CJ, Suarez EA, Zhu Y, Zakoul H, Mogun H, Huybrechts KF. Association of Antipsychotic Drug Exposure in Preganancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study. JAMA Internal Med. 2022 May 1;182(5):522-533. doi: 10.1001/jamainternalmed.2022.0375. PMID: 35343998
  2. Szmulewicz AG, Bateman BT, Levin R, Huybrechts KF. Risk of Overdose Associated With Co-prescription of Antipsychotics and Opioids: A Population-Based Cohort Study. Schizophr Bull. 2022 Mar 1; 48(2):405-413. doi: 10.1093/schbul/sbab116. PMID: 34582543
  3. Straub L, Bateman BT, Hernández-Díaz S, York C, Lester B, Wisner KL, McDougle CJ, Pennell PB, Gray KJ, Zhu Y, Suarez EA, Mogun H, Huybrechts KF. Neurodevelopmental Disorders Among Publicly or Privately Insured Children in the United States. JAMA Psychiatry. 2022 Jan 5:e213815. doi: 10.1001/jamapsychiatry.2021.3815. Epub ahead of print. PMID: 34985527
  4. Sun JW, Hernández-Díaz S, Haneuse S, Bourgeois FT, Vine SM, Olfson M, Bateman BT, Huybrechts KF. Association of Selective Serotonin Reuptake Inhibitors With the Risk of Type 2 Diabetes in Children and Adolescents. JAMA Pscyhiatry. 2021. doi: 10.1001/jamapsychiatry.2020.2762 PMID: 32876659
  5. Straub L, Bateman BT, Hernández-Díaz S, York C, Zhu Y, Suarez EA, Lester B, Gonzalez L, Hanson R, Hildebrandt C, Homsi J, Kang D, Lee KWK, Lee Z, Li L, Longacre M, Shah N, Tukan N, Wallace F, Williams C, Zerriny S, Mogun H, Huybrechts KF. Validity of claims-based algorithms to identify neurodevelopmental disorders in children. Pharmacoepidemiol Drug Saf. 2021 Dec;30(12):1635-1642. doi: 10.1002/pds.5369. Epub 2021 Oct 15. PMID: 34623720
  6. Straub L, Huybrechts KF, Mogun H, Bateman BT. Association of Neuraxial Labor Analgesia for Vaginal Childbirth With Risk of Autism Spectrum Disorder. JAMA Netw Open. 2021 Dec 1;4(21):e2140458. doi: 10.1001/jamanetworkopen.2021.40458. PMID: 34935925
  7. Wisner KL, Oberlander TF, Huybrechts KF. The Association Between Antidepressant Exposure and Birth Defects-Are We There Yet? JAMA Psychiatry. 2020 Dec 1;77(12):1215-1216. doi: 10.1001/jamapsychiatry.2020.1512. PMID: 32777006
  8. Huybrechts KF, Bateman BT, Pawar A, Bessette LG, Mogun H, Levin R, Li H, Motsko S, Scantamburlo Fernandes MF, Upadhyaya HP, Hernández-Díaz S. Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study. BMJ. 2020 Feb 19;368:m237. doi: 10.1136/bmj.m237. PMID: 32075794
  9. Cohen JM, Huybrechts KF, Patorno E, Bateman BT, Desai RJ, Mogun H, Hernández-Díaz S. Anticonvulsant mood stabilizers and lithium use and risk of adverse pregnancy outcomes. The Journal of Clinical Psychiatry 2019;80(4). pii: 18m12572. doi: 10.4088/JCP.18m12572. PMID: 31237992​
  10. Panchaud A, Cohen JM, Patorno E, Huybrechts KF, Desai RJ, Gray KJ, Mogun H, Hernández-Díaz S, Bateman BT. Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study. Neurology. 2018 Aug 7;91(6):e533-e542. doi: 10.1212/WNL.0000000000005944. Epub 2018 Jul 6. PMID: 29980637
  11. Park Y, Hernández-Díaz S, Bateman BT, Cohen JM, Desai RJ, Patorno E, Glynn RJ, Cohen LS, Mogun H, Huybrechts KF. Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes. Am J Psychiatry.2018 Jun 1;175(6):564-574. doi: 10.1176/appi.ajp.2018.17040393. Epub 2018 May 7. PMID: 29730938 
  12. Huybrechts KF, Bröms G, Christensen LB, Einarsdóttir K, Engeland A, Furu K, Gissler M, Hernández-Díaz S, Karlsson P, Karlstad Ø, Kieler H, Lahesmaa-Korpinen AM, Mogun H, Nørgaard M, Reutfors J, Sørensen HT, Zoega H, Bateman BT. Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium. JAMA Psychiatry. 2018 Feb 1;75(2):167-175. doi: 10.1001/jamapsychiatry.2017.3644. PMID: 29238795 
  13. Hernández-Díaz S, Huybrechts KF, Desai RJ, Cohen JM, Mogun H, Pennell PB, Bateman BT, Patorno E.Topiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study. Neurology. 2018 Jan 23;90(4):e342-e351. doi: 10.1212/WNL.0000000000004857. Epub 2017 Dec 27. PMID: 29282333
  14. Huybrechts KF, Bröms G, Brix Christensen L, Einarsdóttir K, Engeland A, Furu K, Gissler M, Hernández-Díaz S, Karlsson P, Karlstad Ø, Kieler H, Lahesmaa-Korpinen A-M, Mogun H, Nørgaard M, Reutfors J, Toft Sørensen H, Zoega H, Bateman BT. Stimulant Use in Pregnancy and Risk of Congenital Malformations: A cohort study from the International Pregnancy Safety Study (InPreSS) Consortium. JAMA Psychiatry. 2018 Feb 1;75(2):167-175. doi: 10.1001/jamapsychiatry.2017.3644. PMID: 29238795
    1. Editorial:  Cooper WO, Shedding light on the risks of methylphenidate and amphetamine in pregnancy. JAMA Psychiatry. 2018 Feb 1;75(2):127-128. doi: 10.1001/jamapsychiatry.2017.3882. PMID: 29238801
  15. Cohen JM, Hernández-Díaz S, Bateman BT, Park Y, Desai RJ, Gray KJ, Patorno E, Mogun H, Huybrechts KF. Placental complications associated with psychostimulant use in pregnancy. Obstet Gynecol. 2017 Dec;130(6):1192-1201. PMID: 29112657
  16. Huybrechts KF, Bateman BT, Desai RJ, Hernández-Díaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E.  Risk of Neonatal Drug Withdrawal after Intrauterine Co-Exposure to Opioids and Psychotropic Medications: A Cohort Study. BMJ 2017;358: p. j3326-j3326 PMID: 28768628
    1. Editorial: Patrick SW, Cooper WO, Davis MM. Prescribing opioids and psychotropic drugs in pregnancy. BMJ 2017; 358: p. j3616-j3616 PMID: 28768614
  17. Patorno E, Huybrechts KF, Hernández-Díaz S. ​Lithium Use in Pregnancy and the Risk of Cardiac Malformations. N Engl J Med. 2017 Aug 31;377(9):893-894. doi: 10.1056/NEJMc1708919. PMID:28854098
  18. Park Y, Huybrechts KF, Cohen JM, Bateman BT, Desai RJ, Patorno E, Mogun H, Cohen LS, Hernández-Díaz S. Antipsychotic Medication Use Among Publicly Insured Pregnant Women in the United States. Psychiatr Serv. 2017 Jun 15:appips201600408. doi: 10.1176/appi.ps.201600408. [Epub ahead of print] PMID: 28617210
  19. Patorno E, Bateman BT, Huybrechts KF, MacDonald SC, Cohen JM, Desai RJ, Panchaud A, Mogun H, Pennell PB, Hernández-Díaz S.  Pregabalin use early in pregnancy and the risk of major congenital malformations.  Neurology. 2017 May 23;88(21):2020-2025. PMID: 28446648
  20. Patorno E, Huybrechts KF, Bateman BT, Cohen JM, Desai RJ, Mogun H, Cohen LS, Hernández-Díaz S. Lithium Use in Pregnancy and the Risk of Cardiac Malformations. NEJM 2017;376:2245-54. PMID: 28854098
  21. Oberg AS, D’Onofrio BD, Rickert ME, Hernández-Díaz S, Ecker JL, Almqvist C, Larsson H, Lichtenstein P, Bateman BT Labor Induction and Offspring Risk of Autism Spectrum Disorders. JAMA Pediatrics. 2016 Jul 25:e160965. PMID: 27454803
    1. Editorial: Coury, DL. What are the facts about autism spectrum disorders, selective serotonin reuptake inhibitors, and assisted reproductive technology? JAMA Pediatrrics. 2016;170(9):e161444. PMID: 27454061
  22. Huybrechts KF, Hernández-Díaz S, Patorno E, Desai RJ, Mogun H, Dejene SZ, Cohen JM, Panchaud A, Cohen L, Bateman BT. Antipsychotic Medication Use in Pregnancy and the Risk for Congenital Malformations. JAMA Psychiatry 2016;73(9):938-46. PMID: 27540849
    1. Editorial: Wisner KL, Jeong H, Chambers C. Use of Antipsychotics During Pregnancy: Pregnant Women Get Sick-Sick Women Get Pregnant. JAMA Psychiatry 2016;73(9):901-3. PMID: 27552366
  23. Palmsten K, Hernández-Díaz S, Chambers CD, Mogun H, Lai S, Gilmer TP, Huybrechts KF. The Most Commonly Dispensed Prescription Medications Among Pregnant Women Enrolled in the U.S. Medicaid Program. Obstet Gynecol. 2015 Sep;126(3):465-73. PMID: 26244530
    1. Editorial: Chescheir NC. Not Your Grandfather's Prescription Pad. Obstet Gynecol. 2015 Sep;126(3):463-4 PMID: 26244526
  24. Huybrechts KF, Palmsten K, Avorn J, Cohen LS, Holmes LB, Franklin JM, Mogun H, Levin R, Kowal M, Setoguchi S, Hernández-Díaz S. Antidepressant Use in Pregnancy and the Risk of Cardiac Defects. The New England Journal of Medicine 2014; 19;370(25):2397-407. PMID: 24941178
  25. Palmsten K, Hernández-Díaz S, Huybrechts KF, Williams PL, Michels KB, Achtyes ED, Mogun H, Setoguchi S. Antidepressant Use Near Delivery and Risk of Postpartum Hemorrhage in a Nationwide US Cohort of Low Income Women. The British Medical Journal 2013 Aug 21;347:f4877. doi: 10.1136/bmj.f4877. PMID: 23965506
  26. Palmsten K, Huybrechts KF, Michels KB, Williams PL, Mogun H, Setoguchi S, Hernández-Díaz S.  Antidepressant Use and Risk for Preeclampsia. Epidemiology. 2013 Sep;24(5):682-691. PMID: 23873072
  27. Huybrechts KF, Palmsten K, Mogun H, Kowal M, Avorn J, Setoguchi-Iwata S, Hernández-Díaz S. National trends in antidepressant medication treatment among publicly-insured pregnant women. General Hospital Psychiatry 2013; 35(3):265-7.1 PMID: 23374897
Opioids
  1. Esposito DB, Bateman B, Werler M, Straub L, Mogun H, Hernández-Díaz S, Huybrechts KF. Ischemic Placental Disease, Preterm Delivery, and Their Association With Opioid Use During Pregnancy. Am J Epidemiol. 2022 Mar 24;191(5):759-768. doi: 10.1093/aje/kwab132. PMID: 34165143
  2. ​Straub L, Huybrechts KF, Hernández-Díaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Trajectories of Prescription Opioid Utilization During Pregnancy Among Prepregnancy Chronic Users and Risk of Neonatal Opioid Withdrawal Syndrome. Am J Epidemiol. 2022 Jan 1;191(1):208-219. doi: 10.1093/aje/kwab249. PMID: 34643225.
  3. Bateman BT, Hernández-Díaz S, Straub L, Zhu Y, Gray KJ, Desai RJ, Mogun H, Gautam N, Huybrechts KF. Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study. BMJ. 2021 Feb 10;372:n102. doi: 10.1136/bmj.n102. PMID: 33568363. 
  4. Straub L, Huybrechts KF, Hernández-Díaz S, Zhu Y, Vine S, Desai RJ, Gray KJ, Bateman BT. Chronic prescription opioid use in pregnancy in the United States. Pharmacoepidemiol Drug Saf. 2021 Apr;30(4):504-513. doi: 10.1002/pds.5194. Epub 2021 Jan 17. PMID: 33428239.
  5. Zhu Y, Huybrechts KF, Desai RJ, Franklin JM, Hernández-Díaz S, Krumme A, Straub L, Neuman M, Wunsch H, Levin R, Mogun H, Bateman BT. Prescription opioid use after vaginal delivery and subsequent persistent opioid use and misuse. Am J Obstet Gynecol MFM. 2021 Mar;3(2):100304. doi: 10.1016/j.ajogmf.2020.100304. Epub 2020 Dec 28. PMID: 33383232​
  6. Sun JW, Franklin JM, Rough K, Desai RJ, Hernández-Díaz S, Huybrechts KF, Bateman BT. Predicting overdose among individuals prescribed opioids using routinely collected healthcare utilization data. PLoS One. 2020. doi: 10.1371/journal.pone.0241083. PMID: 33079968
  7. Gagne JJ, He M, Bateman BT. Trends in Opioid Prescription in Children and Adolescents in a Commercially
    Insured Population in the United States, 2004-2017.JAMA Pediatr. 2019 Jan 1;173(1):98-99. doi: 10.1001/jamapediatrics.2018.3668. PMID: 30419137
  8. Bortoletto P, Prabhu M, Garry EM, Huybrechts KF, Anchan RM, Bateman BT. Opioid Dispensing Patterns After Oocyte Retrieval. Fertil Steril. 2018 Oct;110(5):905-909. doi: 10.1016/k.fertnstert.2018.06.023. PMID: 30316436
  9. Prabhu M, Garry EM, Hernández-Díaz S, MacDonald SC, Huybrechts KF, Bateman BT. Frequency of Opioid Dispensing After Vaginal Delivery. Obstet Gynecol. 2018 Aug;132(2):459-465. doi:10.1097/AOG.0000000000002741. PMID: 29995732 
  10. Rough K, Huybrechts KF, Hernández-Díaz S, Desai RJ, Patorno E, Bateman BT. Using prescription claims to detect aberrant behaviors with opioids: comparison and validation of 5 algorithms. Pharmacoepidemiol Drug Saf. 2018 Apr 24. doi: 10.1002/pds.4443. [Epub ahead of print]. PMID: 29687539
  11. Bateman BT, Cole NM, Maeda A, Burns SM, Houle TT, Huybrechts KF, Clancy CR, Hopp SB, Ecker JL, Ende H, Grewe K, Raposo Corradini B, Schoenfeld RE, Sankar K, Day LJ, Harris LC, Booth JL, Flood P, Bauer ME, Tsen LC, Leffert LR, Landau R. Patterns of opioid prescription and use after cesarean delivery. Obstetrics and Gynecology. 2017 Jul;130(1):29-35. PMID: 28594763
    1. ​Editorial: Patrick, SW. A comprehensive approach to the opioid epidemic. 2017 Jul;130(1):7-9. PMID: 28594781
  12. Desai RJ, Huybrechts KF, Hernández-Díaz S, Mogun H, Patorno E, Kaltenbach K, Kerzner LS, Bateman BT. Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. BMJ. 2015 May 14;350:h2102. PMID: 25975601
  13. Desai RJ, Hernández-Díaz S, Bateman BT, Huybrechts KF. Increase in prescription opioid use during pregnancy among Medicaid-enrolled women.  Obstetrics & Gynecology 2014; 123(5):997-1002. PMID: 24785852
  14. Bateman BT, Hernández-Díaz S, Rathmell J, Seeger JD, Doherty M, Fischer MA, Huybrechts KF. Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance beneficiaries in the United States. Anesthesiology. 2014 May;120(5):1216-24. PMID: 24525628
​Cardiovascular
  1. Bateman BT, Huybrechts KF, Hernández-Díaz S, Kieler H, Zoega H. β-Blocker Use in Pregnancy and the Risk for Congenital Malformations. Ann Intern Med. 2019 Jun 18;170(12):909-910. doi: 10.7326/L19-0157. PMID: 31207630
  2. Bateman BT, Heide-Jørgensen U, Einarsdóttir K, Engeland A, Furu K, Gissler M, Hernández-Díaz S, Kieler H, Lahesmaa-Korpinen AM, Mogun H, Nørgaard M, Reutfors J, Selmer R5, Huybrechts KF, Zoega H. β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study. Annals Of Internal Medicine. 2018 Oct 16. doi: 10.7326/M18-0338 PMID:10.7326/M18-0338
  3. Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Dejene SZ, Fischer MA, Friedman AM, Hernández-Díaz S, Huybrechts KF. Angiotensin-Converting Enzyme Inhibitors and the Risk of Congenital Malformations. Obstet Gynecol. 2017;129(1):174-184. PMID: 27926639
  4. Bateman BT, Patorno E, Desai RJ, Seely EW, Mogun H, Maeda A, Fischer MA, Hernández-Díaz S, Huybrechts KF.  Late Pregnancy β Blocker Exposure and Risks of Neonatal Hypoglycemia and Bradycardia. Pediatrics. 2016 Sep;138(3). pii: e20160731. PMID: 27577580
    • Editorial: Synnes A. Screening for Neonatal Hypoglycemia After Fetal Exposure to β-Blockers. Pediatrics. Sep 2016, 138 (3) e20161691. PMID: 27577577
  5. Bateman BT, Huybrechts KF, Maeda A, Desai R, Patorno E, Seely EW, Ecker JL, Allen-Coleman C, Mogun H, Hernández-Díaz S, Fischer MA. Calcium Channel Blocker Exposure in Late Pregnancy and the Risk of Neonatal Seizures. Obstet Gynecol. 2015 Aug;126(2):271-8. PMID: 26241414
  6. Huybrechts KF, Bateman BT, Palmsten K, Desai RJ, Patorno E, Gopalakrishnan C, Levin R, Mogun H, Hernández-Díaz S. Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA. 2015 Jun 2;313(21):2142-51. PMID: 26034955
  7. Bateman BT; Hernández-Díaz S, Fischer MA; Seely EW; Ecker JL; Franklin JM; Desai RJ; Allen-Coleman C; Mogun H; Avorn J; Huybrechts KF. Statins and congenital malformations: a cohort study. BMJ 2015 Mar 17;350:h1035. PMID: 25784688
    • Editorial: Haramburu F, Daveluy A, Miremont-Salamé G. Statins in pregnancy: new safety data are reassuring, but suspension of treatment is still advisable. BMJ. 2015 Mar 17;350:h1484. PMID: 25784692
  8. Bateman BT, Huybrechts KF, Fischer MA, Seely EW, Ecker JL, Oberg AS, Franklin JM, Mogun H, Hernández-Díaz S. Chronic hypertension in pregnancy and the risk of congenital malformations: a cohort study. Am J Obstet Gynecol. 2015 Mar; 212(3):337.e1-14. PMID: 25265405
  9. Bateman BT, Hernández-Díaz S, Huybrechts KF, Palmsten K, Mogun H, Ecker JL, Seely EW, Fischer MA. Outpatient Calcium Channel Blockers and the Risk of Postpartum Hemorrhage: A Cohort Study. British Journal of Obstetrics and Gynecology 2013;120(13):1668-77. PMID: 24020971
  10. Bateman BT, Hernández-Díaz S, Huybrechts KF, Palmsten K, Mogun H, Ecker JL, Fischer MA. Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population. Hypertension 2012;60(4):913-20. PMID: 22966012
​Rheumatology
  1. Huybrechts KF, Bateman BT, Hernández-Díaz S. Hydroxychloroquine early in pregnancy and risk of birth defects: absence of evidence is not the same as evidence of absence. Am K Obstet Gynecol. 2021 May;224(5):549-550. doi: 10.1016/j.ajog.2020.12.1219. Epub 2021 Jan 9. PMID: 33434554
  2. Huybrechts KF, Bateman BT, Zhu Y, Straub L, Mogun H, Kim SC, Desai RJ, Hernández-Díaz S. Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol. 2021 Mar;224(3):290.e1-290.e22. doi: 10.1016/j.ajog.2020.09.007. Epub 2020 Sep 19. PMID: 32961123
  3. Desai RJ, Bateman BT, Huybrechts KF, Patorno E, Hernández-Díaz S, Park Y, Dejene SZ, Cohen J, Mogun H, Kim SC. Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study. BMJ 2017; 356:j895. PMID: 28264814
  4. Desai RJ, Huybrechts KF, Bateman BT, Hernández-Díaz S, Mogun H, Gopalakrishnan C, Patorno E, Kim SC. Patterns and secular trends in use of immunomodulatory agents during pregnancy in women with rheumatologic conditions. Arthritis Rheumatol. 2016; 68(5):1183-9. PMID: 26606742
HIV
  1. Hernández-Díaz S, Bateman BT, Straub L, Zhu Y, Mogun H, Fischer M, Huybrechts KF. Safety of Tenofovir Disoproxil Fumarate for Pregnant Women Facing the Coronavirus Disease 2019 Pandemic. Am J Epidemiol. 2021 Nov 2;190(11):2339-2349. doi: 10.1093/aje/kwab109. PMID: 33847737
  2. Rough K, Seage GR, Williams PL, Hernández-Díaz S, Huo Y, Chadwick EG, Currier JS, Hoffman RM, Barr E, Shapiro DE, Patel K; PHACS and the IMPAACT P1025 Study Teams. Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine. N Engl J Med. 2018 Apr 26;378(17):1593-1603. doi: 10.1056/NEJMoa1701666. PMID: 29694825
  3. Rough K, Sun JW, Seage GR 3rd, Williams PL, Huybrechts KF, Bateman BT, Hernández-Díaz S. Zidovudine use in pregnancy and congenital malformations: meta-analysis and Bayesian incorporation of medicaid data. AIDS. 2017 Jul 31;31(12):1733-1743. doi: 10.1097/ QAD.0000000000001549. PMID: 28537936
Methods Oriented Publications
  1. Huybrechts KF, Kulldorff M, Hernández-Díaz S, Bateman BT, Zhu Y, Mogun H, Wang SV. Active Surveillance of the Safety of Medications Used During Pregnancy. Am J Epidemiol. 2021 Jun 1;190(6):1159-1168. doi: 10.1093/aje/kwaa288. PMID: 33423046.
  2. Huybrechts KF, Hernández-Díaz S, Bateman BT. Antiemetic Drugs During Pregnancy: What Can We Learn From Spontaneous Reporting System Database Analyses?-Reply. JAMA Pediatr. 2021 Mar 1;175(3):327-328, doi: 10.1001/jamapediatrics.2020.5177. PMID: 33427855
  3. Bateman BT, Huybrechts KF. Drug-drug interactions in pregnancy: An important frontier for pharmacoepidemiology. Paediatr Perinat Epidemiol. 2021 Mar;35(2):194-195. doi. 10.1111/ppe.12733. Epub 2020 Dec 22. PMID: 33350487.
  4. Hernández-Díaz S, Bateman BT, Palmsten K, Schneeweiss S, Huybrechts KF. Using nationally representative survey data for external adjustment of unmeasured confounders: An example using the NHANES data. Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1151-1158. doi: 10.1002/pds.4946. Epub 2019 Dec 20. PMID: 31863536.
  5. Huybrechts KF, Hernández-Díaz S, Bateman BT. Contextualizing Potential Risks of Medications in Pregnancy for the Newborn-the Case of Ondansetron. JAMA Pediatr. 2020 Aug 1; 174(8):747-748. doi. 10.1001/jamapediatrics.2020.1325. PMID: 32478805
  6. Straub L, Huybrechts KF, Bateman BT, Mogun H, Gray KJ, Holmes LB, Hernández-Díaz S. The Impact of Technology on the Diagnosis of Congenital Malformations. Am J Epidemiol. 2019 Nov 1;188(11):1892-1901. doi: 10.1093/aje/kwz153. PMID: 31241162
  7. Huybrechts KF, Bateman BT, Hernández-Díaz S. Use of real-world evidence from healthcare utilization data to evaluate drug safety during pregnancy. Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):906-922. doi: 10.1002/pds.4789. Epub 2019 May 10. PMID: 31074570
  8. MacDonald SC, Cohen JM, Panchaud A, McElrath TF, Huybrechts KF, Hernández-Díaz S. Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance. Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1211-1221. doi: 10.1002/pds.4794. Epub 2019 Jul 22. PMID: 31328328
  9. Hernández-Díaz S, Bateman BT, Palmsten K, Schneeweiss S, Huybrechts KF. Using nationally representative survey data for external adjustment of unmeasured confounders: An example using the NHANES data. Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1151-1158. doi: 10.1002/pds.4946. Epub Dec 20. PMID: 31863536
  10. Desai R, Rothman K, Bateman BT, Hernández-Díaz S, Huybrechts KF. A Propensity-score-based Fine Stratification Approach for Confounding When Exposure is Infrequent. Epidemiology 2017 Mar;28(2):249-257. PMID: 27922533
  11. Rough K, Bateman BT, Patorno E, Desai RJ, Park Y, Hernández-Díaz S, Huybrechts KF. Suppression of substance abuse claims in Medicaid data and Rates of Diagnoses for Non-Substance Abuse Conditions. JAMA 2016; 315(11):1164-6. PMID: 26978213
  12. Swanson SA, Hernández-Díaz S, Palmsten K, Mogun H, Olfson M, Huybrechts KF. Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data. Pharmacoepidemiol Drug Saf. 2015 Sep;24(9):934-42. PMID: 26045370
  13. Palmsten K, Huybrechts KF, Kowal MK, Mogun H, Hernández-Díaz S. Validity of maternal and infant outcomes within nationwide Medicaid data. Pharmacoepidemiol Drug Saf. 2014;23(6):646-55. PMID: 24740606
  14. Palmsten K, Huybrechts KF, Mogun H, Kowal MK, Williams PL, Michels KB, Setoguchi S, Hernández-Díaz S.  Harnessing the Medicaid Analytic eXtract (MAX) to Evaluate Medications in Pregnancy: Design Considerations. PLoS One. 2013 Jun 26;8(6):e67405. PMID: 23840692
  15. Bateman BT, Mhyre JM, Hernández-Díaz S, Huybrechts KF, Fischer MA, Creanga AA, Callaghan WM, Gagne JJ. Development of a comorbidity index for use in obstetric patients. Obstet Gynecol. 2013 Nov;122(5):957-65. PMID: 24104771
    • Editorial: Macrones GA. Understanding and reducing serious maternal morbidity: a step in the right direction. Obstet Gynecol. 2013 Nov;122(5):945-6. PMID: 24104767​
DIABETES
  1. Wood ME, Patorno E, Huybrechts KF, Bateman BT, Gray KJ, Seely EW, Vine S, Hernández-Díaz S. The use of glucose-lowering medications for the treatment of type 2 diabetes mellitus during pregnancy in the United States. Endocrinol Diabetes Metab. 2022 Mar;5(2):e00319. doi: 10.1002/edm2.319. Epub 2021 Dec 24. PMID: 34953068
  2. Wood ME, Chen ST, Huybrechts KF, Bateman BT, Gray KJ, Seely EW, Zhu Y, Mogun H, Patorno E, Hernández-Díaz S. Validation of a Claims-based Algorithm to Identify Pregestational Diabetes Among Pregnant Women in the United States. Epidemiology. 2021 Nov 1;32(6):855-859. doi: 10.1097/EDE.0000000000001397. PMID: 34183529
  3. Sun JW, Hernández-Díaz S, Bourgeois FT, Haneuse S, Brill G, Bateman BT, Huybrechts KF. Antidiabetic medication use in commercially insured children and adolescents in the United States from 2004 to 2019. Diabetes Obes Metab. 2021. doi: 10.1111/dom.14237 PMID: 33118291
  4. Huybrechts KF, Hernández-Díaz S, Straub L, Gray KJ, Zhu Y, Mogun H, Bateman BT. ​Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations.. JAMA. 2019 Nov 15. doi: 10.1001/jama.2019.18587. PMID: 31730152
Respiratory System
  1. Cohen JM, Bateman BT, Huybrechts KF, Mogun H, Yland J, Schatz M, Wurst KE, Hernández-Díaz S. Poorly Controlled Asthma During Pregnancy Remains Common in the United States.  J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2672-2680.e10. doi:10.1016/j.jaip.2019.05.043. Epub 2019 Jun 28. PMID: 31257187
  2. Yland JJ, Bateman BT, Huybrechts KF, Brill G, Schatz MX, Wurst KE, Hernández-Díaz S.Perinatal Outcomes Associated with Maternal Asthma and its Severity and Control during Pregnancy.J Allergy Clin Immunol Pract. 2020 Jan 22. doi:10.1016/j.jaip.2020.01.016. Epub 2020 Jan 22. PMID: 31981730
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PEDIATRICS​
  1. Sun JW, Bourgeois FT, Haneuse S, Hernández-Díaz S, Landon JE, Bateman BT, Huybrechts KF. Development and Validation of a Pediatric Comorbidity Index. Am J Epidemiol. 2021 May 4;190(5):918-927. doi: 10.10093/aje/kwaa244. PMID: 33124649
OTHER
  1. Broms G, Friedman S, Kim SC, Wood ME, Hernández-Díaz S, Brill G, Bateman BT, Huybrechts KF, Desai RJ. The Patterns of Use of Medications for Inflammatory Bowel Disaese During Pregnancy in the US and Sweden Are Changing. Inflamm Bowel Dis. 2021 Aug 19;27(9):1427-1434. doi: 10.1093/ibd/izaa294. PMID: 33751058
  2. Zhu Y, Bateman BT, Gray KJ, Hernández-Díaz S, Mogun H, Straub L, Huybrechts KF. Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. BMJ. 2020 May 20;369:m1494. doi: 10.1136/bmj.m1494. PMID: 32434758
  3. Huybrechts KF, Hernández-Díaz S, Straub L, Gray KJ, Zhu Y, Mogun H, Bateman BT. Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations. JAMA. 2020 Jan 28;323(4):372-374. doi: 10.1001/jama.2019.18587. PMID: 31730152
  4. Straub L, Huybrechts KF, Mogun H, Bateman BT. Association of Neuraxial Labor Analgesia for Vaginal Childbirth With Risk of Autism Spectrum Disorder. JAMA Netw Open. 2021 Dec 1;4(12):e2140458. doi: 10.1001/jamanetworkopen.2021.40458. PMID: 34935925
  5. Huybrechts KF, Hernández-Díaz S, Straub L, Gray KJ, Zhu Y, Patorno E, Desai RJ, Mogun H, Bateman BT. Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring. JAMA. 2018 Dec 18;320(23):2429-2437. doi: 10.1001/jama.2018.18307. PMID: 30561479
H4P is a program of Harvard T.H. Chan School of Public Health and the Division of Phamacoepidemiology & Pharmacoeconomics 
Department of Medicine at Brigham & Women's Hospital and Harvard Medical School
1620 Tremont Street Suite 3030 | Boston, MA 02120 | 617-278-0930​ | h4p@bwh.harvard.edu